Fatty Acid Metabolism during Exercise

The Dynamics of Plasma Free Fatty Acid Metabolism during Exercise.

[Regulation of glucose and fatty acid metabolism in the skeleton muscle during physics exercise].

Carta-resposta ao leitor Em resposta à apreciação do estudo, destaco que as considerações são relevantes no seu aspecto geral, incluindo os efeitos do ciclo glicose-ácido graxo durante o exercício intenso. Como previamente mencionado, existe uma competição entre glicose e ácidos graxos (AG) como substratos para a síntese de ATP nos músculos esquelético e cardíaco e nos adipócitos. Nesse process...

Fatty acid kinetics and carbohydrate metabolism during electrical exercise in spinal cord-injured humans.

Motor center activity and reflexes from contracting muscle have been shown to be important for mobilization of free fatty acids (FFA) during exercise. We studied FFA metabolism in the absence of these mechanisms: during involuntary, electrically induced leg cycling in individuals with complete spinal cord injury (SCI). Healthy subjects performing voluntary cycling served as controls (C). Ten SC...

Impaired Fatty Acid Metabolism

To establish whether insulin resistance and/or postprandial fatty acid metabolism might contribute to familial combined hyperlipidemia (FCH) we have examined parameters of insulin resistance and lipid metabolism in six FCH kindreds. Probands and relatives (n = 56) were divided into three tertiles on the basis of fasting plasma triglycerides (TG). Individuals in the highest tertile (TG > 2.5 mM;...

Heart-type fatty acid-binding protein reciprocally regulates glucose and fatty acid utilization during exercise.

The role of heart-type cytosolic fatty acid-binding protein (H-FABP) in mediating whole body and muscle-specific long-chain fatty acid (LCFA) and glucose utilization was examined using exercise as a phenotyping tool. Catheters were chronically implanted in a carotid artery and jugular vein of wild-type (WT, n = 8), heterozygous (H-FABP(+/-), n = 8), and null (H-FABP(-/-), n = 7) chow-fed C57BL/...